A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
Blog Article
Using one-molecule optical and AFM imaging and pressure-spectroscopy strategies, we look for to unravel the mechanistic components of the framework and dynamics of chromosomes. Our analysis interests involve:
1996, first mesoscopic cost density waves products; and initial electrical measurements on an individual metallic nanocluster involving nanoelectrodes
Dynamics of initiation, termination and reinitiation of DNA translocation from the motor protein EcoR124I
2007, initially true-time detection of strand Trade in homologous recombination by RecA; discovery of a minimal persistence duration of finishes of microtubules; and resolved the mechanism of biosensing with carbon nanotubes
We build stage-of-treatment diagnostics examination of neglected tropical ailments inside useful resource-confined options, depending on Crspr/Cas9 detecting of pathogen’s DNA in physique fluids.
Our investigation ranges through the biophysics of DNA to artificial cells and over and above. Remember to take a look underneath for the spectrum of our recent initiatives.
All parameters have been exactly the same for each panel in this video, except for the Preliminary placement on the 6hb rod (demonstrated in blue) to the nanopore. Simulations that terminated early as a consequence of translocation from the rod with the pore are marked by a grey qualifications.
2011, initially in vitro measurements of transport throughout an individual biomimetic nuclear pore complicated; enhancement of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the mechanism of homology recognition in DNA homologous recombination
‘You should not just give thought to the inquiries of cees dekker tomorrow, but in addition consider the inquiries from the working day after tomorrow’
‘The fantastically refined way wherein elements in nature perform in no way ceases to amaze me. If we address the puzzle of how life came into becoming, I anticipate that my amazement within the complexity of generation could have enhanced and with it my awe to the greatness in the Creator.’
Illustration (4) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is demonstrated in grey, the rim on the pore is highlighted in red, as well as a 3D rendering from the movement of your DNA rod is exhibited.
Afterwards we spoke once again briefly mainly because Dekker felt that our dialogue of his religion rapidly became purely philosophical, While What's more, it concretely allows him in his work.
2005, discovery from the system of DNA uncoiling by topoisomerase enzymes; discovery of long-selection conformational changes in Mre11/DNA mend complexes; and first power measurements over a DNA molecule inside a nanopore
It was an incredibly attention-grabbing time, in the course of which I gained a lot of help from Delft College of Technological know-how, exactly where I used to be a professor at enough time, And that i begun a number of collaborations with molecular biologists. That assisted me understand lots.’